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pentobarbital will reduce the level or impact of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Pitolisant exposure is decreased by fifty% if coadministered with sturdy CYP3A4 inducers.pentobarbital will decrease the level or result of nitrendipine by affecting hepatic/intestinal enzyme CYP3A4 me